Project Background
Titel: MDR in AIS
Minimizing Door to Reperfusion Times in Drip and Ship Model for Patients with Acute Ischemic Stroke (MDRinAIS) aims to optimize the in-hospital workflow for LVO AIS patients transferred to CSCs for MT.
Challenges addressed:
1. Treatment Timeliness: Streamlining the workflow for secondarily transferred patients minimizes time to treatment, preserving brain function, reducing disability and long-term costs.
2. Complex Time-Dependent Stroke Networks Implementation: Optimizing coordination between primary stroke centers (PSCs), CSCs, and healthcare system. Addressing delays in recommended time targets for MT due to transfers, coordination challenges, and admittance procedures at the CSC’s ED.
3. Feasibility and Implementation of Streamlined Pathways: Proposing a direct transfer pathway bypassing CSC’s ED to reduce doorto-groin(DTG)time and improve outcomes. Feasibility depends on available resources.
4. Variations in Healthcare Systems and Practices: Recognizing unique challenges due to variations among different healthcare systems, and considering evidence-based strategies adaptable to diverse settings. Facing with factors such as cultural differences, economic sustainability and benefits for healthcare systems.
5. Technological Advancements and Implementation: Acknowledging telemedicine potential in streamlining AIS care workflows. Addressing technological literacy among healthcare providers, system integration, and data privacy. The insights gained will be applicable to different clinical settings, ultimately improving services for all patients.
6. Resource Allocation Optimization: Implementing distributed health and care models to optimize resource allocation in time-sensitive and critical settings such as stroke care. Alleviating burden on emergency care facilities, enhancing stroke care delivery through timely interventions and continuous monitoring. Improving the efficiency of healthcare resources and patient outcomes, with consequent cost savings.
Project Facts
Duration
03/2024 to 03/2027 (36 month)
Programme
European Partnership on Transforming Health and Care Systems (THCS)
European Union under the Horizon Europe Framework Programme –
Grant Agreement No. 101095654 (FFG grant agreement No. 50773503).
Identification Code
FP-1127
Project Objectives
Project Structure
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WP1 |
Project & Risk Management and Coordination WP1 focuses on coordinating consortium partners, establishing efficient communication and data sharing mechanisms, and ensuring proper administrative, ethical, and risk management throughout the project. Financial aspects pertaining to the project will be handled by each individual partner in collaboration with their Funding Organization. |
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WP2 |
Evaluation of In-Hospital Workflow and Retrospective Data WP2 aims to evaluate the timing of the current in-hospital workflow and collect and analyze retrospective clinical and outcome data for comparison. |
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WP3 |
Streamlined In-Hospital Pathway Development WP3 aims to develop a standardized pathway for AIS patients eligible for MT to streamline the in-hospital workflow. |
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WP4 |
Patient Selection, Study Criteria Definition and Data Collection WP4 aims to establish criteria for patient selection and study criteria for both retrospective and prospective components of the multicentric clinical trial, data collection for the prospective study. |
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WP5 |
Telemedicine System Selection and Implementation WP5 aims to implement a telemedicine application for direct and real-time sharing of patient medical data and imaging data. |
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WP6 |
Statistical Analysis and Result Processing WP6 aims to support project coordinator and teams involved in study design, data collection, data preparation and preprocessing, statistical analysis on collected data and reporting. |
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WP7 |
Health Economic Impact Evaluation WP7 aims to assess the economic sustainability and benefits of the streamlined pathway for AIS management. It also involves collecting policy data related to AIS management workflows in different European contexts |
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WP8 |
Communication, Dissemination, Exploitation, and Networking WP8 aims to disseminate project findings, develop an exploitation plan, establish an online presence, and engage with initiatives and networks funded by the EU or other national programs. |
Deliverables
WP1 | D1.1 | Project management plan |
WP1 | D1.2 | Risk management and quality plan |
WP1 | D1.3 | Data management plan / GDPR (Version 1) |
WP1 | D1.4 | Ethics framework and guidelines for the ethical committee |
WP1 | D1.5 | Data management plan / GDPR (Version 2) |
WP2 | D2.1 | Case report form for retrospective data collection in clinical settings |
WP2 | D2.2 | Anonymized and compliant sharable database of retrospective data |
WP2 | D2.3 | Sharable database with anonymized retrospective data |
WP3 | D3.1 | Stakeholder analysis report |
WP3 | D3.2 | Standardized approved and coordinated streamlined pathways for AIS patients |
WP3 | D3.3 | Trainings and capacity programs |
WP4 | D4.1 | Implementation and integration of telemedicine system |
WP4 | D4.2 | Evaluation report on the effectiveness of the telemedicine system |
WP5 | D5.1 | Prospective clinical and outcome data report (Version 1) |
WP5 | D5.2 | Prospective clinical and outcome data report (Version 2) |
WP5 | D5.3 | Data collection and case report forms |
WP5 | D5.4 | Prospective clinical and outcome data report (Version 3) |
WP5 | D5.5 | Statistical analysis and modeling summary report |
WP6 | D6.1 | Comparative Analysis Report |
WP7 | D7.1 | Dissemination and Communication plan (Version 1) |
WP7 | D7.2 | Online and media presence (Version 1) |
WP7 | D7.3 | Dissemination and Communication plan (Version 2) |
WP7 | D7.4 | Dissemination and Communication plan (Version 3) |
WP7 | D7.5 | Exploitation strategy |
WP7 | D7.6 | Online and media presence (Version 1) |
WP7 | D7.7 | Engagement summary report |